Immunization with a live attenuated H7N9 influenza vaccine protects mice against lethal challenge.
Identifieur interne : 000556 ( Main/Exploration ); précédent : 000555; suivant : 000557Immunization with a live attenuated H7N9 influenza vaccine protects mice against lethal challenge.
Auteurs : Xiaolan Yang [République populaire de Chine] ; Jianyu Zhao [République populaire de Chine] ; Cheng Wang [République populaire de Chine] ; Yueqiang Duan [République populaire de Chine] ; Zhongpeng Zhao [République populaire de Chine] ; Rui Chen [République populaire de Chine] ; Liangyan Zhang [République populaire de Chine] ; Li Xing [République populaire de Chine] ; Chengcai Lai [République populaire de Chine] ; Shaogeng Zhang [République populaire de Chine] ; Xiliang Wang [République populaire de Chine] ; Penghui Yang [République populaire de Chine]Source :
- PloS one [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Animals, Female, Humans, Immunization, Influenza A Virus, H7N9 Subtype (immunology), Influenza Vaccines (immunology), Influenza, Human (prevention & control), Influenza, Human (virology), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (virology).
- MESH :
- chemical , immunology : Influenza Vaccines.
- immunology : Influenza A Virus, H7N9 Subtype.
- prevention & control : Influenza, Human, Orthomyxoviridae Infections.
- virology : Influenza, Human, Orthomyxoviridae Infections.
- Animals, Female, Humans, Immunization, Mice, Mice, Inbred BALB C.
Abstract
The emergence of severe cases of human influenza A (H7N9) viral infection in China in the spring of 2003 resulted in a global effort to rapidly develop an effective candidate vaccine. In this study, a cold-adapted (ca), live attenuated monovalent reassortant influenza H7N9 virus (Ah01/AA ca) was generated using reverse genetics that contained hemagglutinin (HA) and neuraminidase (NA) genes from a 2013 pandemic A H7N9 isolate, A/Anhui/01/2013 virus (Ah01/H7N9); the remaining six backbone genes derived from the cold-adapted influenza H2N2 A/Ann Arbor/6/60 virus (AA virus). Ah01/AA ca virus exhibited temperature sensitivity (ts), ca, and attenuation (att) phenotypes. Intranasal immunization of female BALB/c mice with Ah01/AA ca twice at a 2-week interval induced robust humoral, mucosal, and cell-mediated immune responses in a dose-dependent manner. Furthermore, the candidate Ah01/AA ca virus was immunogenic and offered partial or complete protection of mice against a lethal challenge by the live 2013 influenza A H7N9 (A/Anhui/01/2013). Protection was demonstrated by the inhibition of viral replication and the attenuation of histopathological changes in the challenged mouse lung. Taken together, these data support the further evaluation of this Ah01/AA ca candidate vaccine in primates.
DOI: 10.1371/journal.pone.0123659
PubMed: 25884801
Affiliations:
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type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chen, Rui" sort="Chen, Rui" uniqKey="Chen R" first="Rui" last="Chen">Rui Chen</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.</nlm:affiliation><country xml:lang="fr">République 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sortKey="Duan, Yueqiang" sort="Duan, Yueqiang" uniqKey="Duan Y" first="Yueqiang" last="Duan">Yueqiang Duan</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhao, Zhongpeng" sort="Zhao, Zhongpeng" uniqKey="Zhao Z" first="Zhongpeng" last="Zhao">Zhongpeng Zhao</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chen, Rui" sort="Chen, Rui" uniqKey="Chen R" first="Rui" last="Chen">Rui Chen</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lai, Chengcai" sort="Lai, Chengcai" uniqKey="Lai C" first="Chengcai" last="Lai">Chengcai Lai</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Shaogeng" sort="Zhang, Shaogeng" uniqKey="Zhang S" first="Shaogeng" last="Zhang">Shaogeng Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing 302 Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yang, Penghui" sort="Yang, Penghui" uniqKey="Yang P" first="Penghui" last="Yang">Penghui Yang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China; Beijing 302 Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China; Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Female</term><term>Humans</term><term>Immunization</term><term>Influenza A Virus, H7N9 Subtype (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (virology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Orthomyxoviridae Infections (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Immunisation</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H7N9 du virus de la grippe A (immunologie)</term><term>Vaccins antigrippaux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H7N9 du virus de la grippe A</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H7N9 Subtype</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Humans</term><term>Immunization</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Immunisation</term><term>Infections à Orthomyxoviridae</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The emergence of severe cases of human influenza A (H7N9) viral infection in China in the spring of 2003 resulted in a global effort to rapidly develop an effective candidate vaccine. In this study, a cold-adapted (ca), live attenuated monovalent reassortant influenza H7N9 virus (Ah01/AA ca) was generated using reverse genetics that contained hemagglutinin (HA) and neuraminidase (NA) genes from a 2013 pandemic A H7N9 isolate, A/Anhui/01/2013 virus (Ah01/H7N9); the remaining six backbone genes derived from the cold-adapted influenza H2N2 A/Ann Arbor/6/60 virus (AA virus). Ah01/AA ca virus exhibited temperature sensitivity (ts), ca, and attenuation (att) phenotypes. Intranasal immunization of female BALB/c mice with Ah01/AA ca twice at a 2-week interval induced robust humoral, mucosal, and cell-mediated immune responses in a dose-dependent manner. Furthermore, the candidate Ah01/AA ca virus was immunogenic and offered partial or complete protection of mice against a lethal challenge by the live 2013 influenza A H7N9 (A/Anhui/01/2013). Protection was demonstrated by the inhibition of viral replication and the attenuation of histopathological changes in the challenged mouse lung. Taken together, these data support the further evaluation of this Ah01/AA ca candidate vaccine in primates. </div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Xiaolan" sort="Yang, Xiaolan" uniqKey="Yang X" first="Xiaolan" last="Yang">Xiaolan Yang</name></noRegion><name sortKey="Chen, Rui" sort="Chen, Rui" uniqKey="Chen R" first="Rui" last="Chen">Rui Chen</name><name sortKey="Duan, Yueqiang" sort="Duan, Yueqiang" uniqKey="Duan Y" first="Yueqiang" last="Duan">Yueqiang Duan</name><name sortKey="Lai, Chengcai" sort="Lai, Chengcai" uniqKey="Lai C" first="Chengcai" last="Lai">Chengcai Lai</name><name sortKey="Wang, Cheng" sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name><name sortKey="Yang, Penghui" sort="Yang, Penghui" uniqKey="Yang P" first="Penghui" last="Yang">Penghui Yang</name><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name><name sortKey="Zhang, Shaogeng" sort="Zhang, Shaogeng" uniqKey="Zhang S" first="Shaogeng" last="Zhang">Shaogeng Zhang</name><name sortKey="Zhao, Jianyu" sort="Zhao, Jianyu" uniqKey="Zhao J" first="Jianyu" last="Zhao">Jianyu Zhao</name><name sortKey="Zhao, Zhongpeng" sort="Zhao, Zhongpeng" uniqKey="Zhao Z" first="Zhongpeng" last="Zhao">Zhongpeng Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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